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Highway hypnosis usually occurs when you are driving on a fairly long, straight road at a consistent speed. The hum of the wind, tires and sound of the engine also add to the hypnosis.  Your body becomes relaxed and your brain becomes passive to the events around you.  Highway hypnosis might even make you sleepy.

What can you do to avoid this situation?

Before Driving

• Get enough rest before starting any trip.
• Avoid alcoholic beverages and heavy food.
• Avoid long drives at night if possible.
• Don’t drive during your normal sleeping hours.
• Begin the trip early in the day.
• Beware of any medications that can impair your driving ability.

While Driving

• Don’t use cruise control – keep your body involved with driving.
• Limit long distance driving – take breaks at least every two hours.
• Don’t try to drive too far in one day.
• Keep your eyes moving and check your mirrors often.
• Wear sunglasses during the day to cut glare.
• Keep the car temperature cool, turn the radio volume up and avoid soft, sleep-inducing music.
• If possible, share driving responsibilities with someone else.
• Look at all the road signs and traffic around you.
• Before you get too sleepy, find a safe, guarded rest area and take a nap.

Remember to be safe at all times. 
Sources:
http://www.dsao.com/drivingtip.cfm?tipno=18
http://www.dor.state.ne.us/rca/docs/4-Lane-Hwy.pdf
http://www.ndsc.org/Safetytalk.asp
http://www.safety-council.org/info/traffic/wake-up.html